About RMG- Rapid Mixer Granulator - Part - 4/4 - Rx Pharma Knowledge

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Sunday, February 7, 2021

About RMG- Rapid Mixer Granulator - Part - 4/4



Components & Process parts of RMG:


 

Here mention Components & Process parts of RMG not limited. It’s varying as per manufacturer of machine.

  • RMG consists of different Components like:

  1. Mixing chamber
  2. Impeller
  3. Chopper
  4. Binder Inlet port
  5. End Point
  6. Top Lid
  7. Discharge point
  8. Purging air
  9. Filter Assembly
  10. Co-mill
  11. CIP (Clean-in-Place) / WIP (Wash-in-Place) System
  12. Control panel like HMI, IPC or PLC Programmable Logic Controller (PLC)

  • Other Information about RMG:

  1. PRINCIPLE OF RAPID MIXER GRANULATOR
  2. General Process in RMG
  3. Calculate For working capacity of the Rapid mixture granulator?
  4. Process variable of RMG:
  5. Advantage:
  6. Disadvantage:
  7. Safety Features

 1 : PRINCIPLE OF RAPID MIXER GRANULATOR

 

The Rapid Mixer Granulator is mixing equipment that contains bottom entry agitator/impeller and side-mounted chopper for effective granulation of materials in various industries. The RMG Machine is used for the applications of wet mixing, dry blending/mixing, and preparation of dough & granulation.

After loading the ingredients in the RMG mixing chamber the formation of granules occurs by the impeller which sets the entire mixture in a spinning tumbling motion which results in distribution of all dry granules as well as Wet granules.

In Rapid mixer granulator Mixing ,Densification and Agglomeration is achieved using Shear mixing(Breaking inter-molecular forces) and Compaction forces exerted by Impeller on the powder mass.

The components of the RMG (impeller and chopper) are highly responsible for the wet granulation process.

 

Rapid mixture granulator works on agitation, tumbling. The impeller is responsible for uniformly mixing wet granules and copper helps in a break or reduced particle size. At the starting process or during binder addition impeller and chopper are operated at low speed and then after the formation of wet mass, they are operated at high speed to make the desired granule size.

Dry mixing is done at high speed after adding all dispensed materials into RMG.

 

2 : General Process in RMG

Dry mixing takes about 3-5 minutes to mix the ingredients; wet mixing takes 5-10 minutes to make the material’s wet mass. The granulation process takes 5-10 minutes to 0.5 mm to 1.5 mm sized granules.

 

Mixing time consumed in processing is depends upon the ingredient’s quantity and their particle size.

Dry Mixing: Impeller operated at a lower speed (75 RPM ) or as per BMR at starting during dry mixing of dispensed materials as per Product – BMR. Its time depend on BMR like 5 to 10 min for uniform dry mixing before binding for uniform granules. After completion of Dry Mixing go for Wet Mixing or Binding.

Binder addition: Add the Paste or Binder solution through binder inlet or addition port by  operated impeller  at a validate speed of impeller rpm for products or as given in batch manufacturing records (BMR). ( RPM: 75 to 150 RPM)

 

3 : Calculate For working capacity of the Rapid mixture granulator?

For this first calculate the bulk density of powder to be mixed, then it multiplies by the capacity in liters (provided by the vendor), for eg.

working capacity in a liter is 600 liter and its working volume is 80% means 480 liters and bulk density is 0.5 then capacity in kgs is 480*0.5= 240 kg.

so we can make a batch of 240 kg materials in modal of 600 liters RMG.

4 : Process variable of RMG:

Time was taken during the mixing process

Speed of impeller

Speed of chopper

Binder solution quantity

Impeller rotation speed

Chopper rotation speed

Liquid flow rate

Load of the mixer

Liquid addition method

Wet-massing time (subsequent of liquid addition time)

 

5. Advantage:

Easy to operate from PLC panel

Required less time for clean and easy to clean

Safety is adequate

Standardized according to GMP

Self-discharge

Mixing can be performed at large scale at less time

Can produce Homogenous mass and later on granules in less time.

6. Disadvantage:

High noise level

Required large space to install

During the process, temperature becomes high because of friction force between granules.

High in cost

Working height is more, so required more effort to add materials.

 

7. SAFETY FEATURES

All belts, pulleys and transmission system are adequately guarded with suitable covers.

Machine can't be started if the top lid is open due to a proximity sensor.

Machine can't be started if the air pressure is below the set value.

Machine can't be started if the discharge flange is open for cleaning due to a proximity sensor.

If main impeller is lifted upward for cleaning or for visual inspection during validation of cleaning, the machine can't be switched ON.

Machine can't be started unless Fluid bed trolley us kept underneath discharge assembly.

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